Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.

ABSTRACT: Hepatic CD4 tissue-resident memory T cells (TRM) are required for robust protection against Salmonella infection; however, the generation of this T cell population is poorly understood. To interrogate the contribution of inflammation, we developed a simple Salmonella-specific T cell transfer system that allowed direct visualization of hepatic TRM formation. Salmonella-specific (SM1) T cell receptor (TCR) transgenic CD4 T cells were activated in vitro and adoptively transferred into C57BL/6 mice while hepatic inflammation was induced by acetaminophen overdose or L. monocytogenes infection. In both model systems, hepatic CD4 TRM formation was accentuated by local tissue responses. Liver inflammation also enhanced the suboptimal protection provided by a subunit

SUBMITTER: Depew CE 

PROVIDER: S-EPMC10120061 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature