Signatures in in vitro infection of NSC-34 mouse neurons and their cell nucleus with Rickettsia helvetica.

ABSTRACT:

Background

Rickettsia helvetica, a spotted fever rickettsia, is transmitted to humans via ticks in Europe, North Africa, and Asia. The central nervous system is a crucial target for rickettsial diseases, which has been reported for 12 of the 31 species, of which R. helvetica is one. This study aimed, in an experimental model, to identify characteristics of R. helvetica infection in a mouse neuronal cell line, NSC-34.

Results

NSC-34, a fusion cell line of mouse motor spinal cord neurons and neuroblastoma cells, was used as a model. Propagation of R. helvetica in neurons was confirmed. Short actin tails were shown at the polar end of the bacteria, which makes it likely that they can move intracellularly, and even spread between cells. Another protein, Sca4, which with the cell

SUBMITTER: Kask L 

PROVIDER: S-EPMC10120103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature