Tumor-infiltrating CD36⁺CD8⁺T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer.

ABSTRACT:

Background

The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8⁺ T cells, but the clinical role remains obscure. This study aims to explore the infiltration and clinical value of CD36⁺CD8⁺ T cells in NSCLC.

Methods

Immunohistochemistry and immunofluorescence were conducted for survival analyses and immunological evaluation in 232 NSCLC patients in Zhongshan Hospital. Flow cytometry analyses were carried out to assess the immune cells from fresh tumor samples, non-tumor tissues and peripheral blood. In vitro tumor infiltrating lymphocytes cultures were conducted to test the effect of CD36 blockage.

Results

Accumulation of CD36⁺CD8⁺ T cells in tumor tissues was correlated with mo

SUBMITTER: Ao YQ 

PROVIDER: S-EPMC10120154 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature