Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis.

ABSTRACT:

Background

Migraine is a complex neurological disorder that is characterized by a "lower threshold of neuronal hyperexcitability" with distinctive periodicity and complex vascular dysfunction. Genetic factors have impacted incredibly on the susceptibility of migraine and one such example is the TNF-α 308G > A.

Aim

Therefore, we aim to provide a glimpse of the association of the TNF-α 308G > A risk on the susceptibility of migraine.

Method

The pooled odds ratio with the associated 95% of confidence interval were calculated using different genetic models. Heterogeneity was accessed by using Cochran's Q Test and I² statistics and Begg's and Egger's tests were used for finding the publication bias, tests were two-sided, and a p-value of < 0.05 was considered st

SUBMITTER: Sudershan A 

PROVIDER: S-EPMC10120225 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature