The senescence difference between the central and peripheral cornea induced by sutures.

ABSTRACT:

Introduction

Cell senescence plays a regulatory role in tissue fibrosis. Corneal scarring is usually more severe in the central cornea based on clinical observation. In this study, we attempted to explore the senescence difference between the central and peripheral cornea in an in vivo mouse model with suture-induced senescence and in an in vitro model of senescence with hydrogen peroxide (H₂O₂)-induced rabbit corneal fibroblasts.

Methods

Male Balb/c mice (6-8 weeks) received sutures in the central, superior, inferior, nasal, and temporal cornea. The sutures were removed on the 14th day. Corneal neovascularization was observed under a slit lamp microscope with a digital camera. The fibroblasts isolated from the central and peripheral rabbit cornea were

SUBMITTER: Li S 

PROVIDER: S-EPMC10120248 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature