Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles.

ABSTRACT:

Introduction

The transition to metabolically unhealthy obesity (MUO) is driven by the limited expandability of adipose tissue (AT). Familial Partial Lipodystrophy type 2 (FPLD2) is an alternative model for AT dysfunction that is suitable for comparison with obesity. While MUO is associated with low-grade systemic inflammation, studies of inflammation in FPLD2 have yielded inconsistent results. Consequently, comparison of inflammation markers between FPLD2 and obesity is of great interest to better understand the pathophysiological defects of FPLD2.

Objective

To compare the levels of inflammatory biomarkers between a population of patients with FPLD2 due to the same 'Reunionese' LMNA variant and a population of patients with obesity (OB group).

Methods

Adiponectin, lep

SUBMITTER: Treiber G 

PROVIDER: S-EPMC10120265 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature