Rod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structure.

ABSTRACT:

Purpose

To characterize the association between dark-adapted rod and cone sensitivity and retinal structure in PAX6-related aniridia.

Methods

Dark-adaptation curves were measured after a 5-minute exposure to bright light with red (625 nm) and green (527 nm) 2° circular light stimuli presented at ≈20° temporal retinal eccentricity in 27 participants with aniridia (nine males; 11-66 years old) and 38 age-matched healthy controls. A two-stage exponential model was fitted to each participant's responses to determine their cone and rod thresholds over time. The thicknesses of macular inner and outer retinal layers were obtained from optical coherence tomography images in 20 patients with aniridia and the 38 healthy controls. Aniridia-associated keratopathy (AAK) grade (0-3) and l

SUBMITTER: Pedersen HR 

PROVIDER: S-EPMC10120381 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature