Cocaine Seeking And Taking Are Oppositely Regulated By Dopamine.

ABSTRACT: In some individuals, drug-associated cues subsume potent control of behavior, such as the elicitation of drug craving^1-3 and automatized drug use⁴. The intensity of this cue reactivity is highly predictive of relapse and other clinical outcomes in substance use disorders^5,6. It has been postulated that this cue reactivity is driven by augmentation of dopamine release over the course of chronic drug use⁷. Here we carried out longitudinal recording and manipulation of cue-evoked dopamine signaling across phases of substance-use related behavior in rats. We observed a subset of individuals that exhibited increased cue reactivity and escalated drug consumption, two cardinal features of substance use disorders. In these individuals, cue-evoked phasic

SUBMITTER: Burgeno LM 

PROVIDER: S-EPMC10120672 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature