Developing an evolutionary baseline model for humans: jointly inferring purifying selection with population history.

ABSTRACT: Building evolutionarily appropriate baseline models for natural populations is not only important for answering fundamental questions in population genetics - including quantifying the relative contributions of adaptive vs. non-adaptive processes - but it is also essential for identifying candidate loci experiencing relatively rare and episodic forms of selection ( e.g., positive or balancing selection). Here, a baseline model was developed for a human population of West African ancestry, the Yoruba, comprising processes constantly operating on the genome ( i.e. , purifying and background selection, population size changes, recombination rate heterogeneity, and gene conversion). Specifically, to perform joint inference of selective effects with demography, an approximate Baye

SUBMITTER: Johri P 

PROVIDER: S-EPMC10120674 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature