<i>MAPT</i> expression is mediated by long-range interactions with <i>cis</i>-regulatory elements.

ABSTRACT:

Background

Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the MAPT gene. MAPT expression is absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic expression pattern suggests that MAPT expression is controlled by transcription factors and cis-regulatory elements specific to differentiated cell types. Given the relevance of MAPT expression to neurodegeneration pathogenesis, identification of such elements is relevant to understanding genetic risk factors.

Methods

We performed HiC, chromatin conformation capture (Capture-C), single-nucleus multiomics (RNA-seq+ATAC-seq), bulk ATAC-seq, and ChIP-seq for H3K27Ac and C

SUBMITTER: Rogers BB 

PROVIDER: S-EPMC10120716 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature