Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.

ABSTRACT: The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. Here we directly compare cortical dynamics during internally- versus externally-driven locomotion using wide-field Ca²⁺ imaging. We find that secondary motor cortex (M2) plays a larger role in internally-driven spontaneous locomotion transitions, with increased M2 functional connectivity during starting and stopping than in the externally-driven, motorized treadmill locomotion. This is not the case in steady-state walk. In addition, motorized treadmill and spontaneous locomotion are characterized by markedly different patterns of cortical activ

SUBMITTER: West SL 

PROVIDER: S-EPMC10120783 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature