Bacterial community modifies host genetics effect on early childhood caries.

ABSTRACT:

Background

By age five approximately one-fifth of children have early childhood caries (ECC). Both the oral microbiome and host genetics are thought to influence susceptibility. Whether the oral microbiome modifies genetic susceptibility to ECC has not been tested. We test whether the salivary bacteriome modifies the association of a polygenic score (PGS, a score derived from genomic data that summarizes genetic susceptibility to disease) for primary tooth decay on ECC in the Center for Oral Health Research in Appalachia 2 longitudinal birth cohort.

Methods

Children were genotyped using the Illumina Multi-Ethnic Genotyping Array and underwent annual dental examinations. We constructed a PGS for primary tooth decay using weights from an independent, genome-wide association me

SUBMITTER: Blostein F 

PROVIDER: S-EPMC10120800 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature