Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis.

ABSTRACT: The host genome may influence the composition of the intestinal microbiota, and the intestinal microbiota has a significant effect on muscle growth and development. In this study, we found that the deletion of the myostatin (MSTN) gene positively regulates the expression of the intestinal tight junction-related genes TJP1 and OCLN through the myosin light-chain kinase/myosin light chain pathway. The intestinal structure of MSTN^-/- pigs differed from wild-type, including by the presence of a thicker muscularis and longer plicae. Together, these changes affect the structure of intestinal microbiota. Mice transplanted with the intestinal microbiota of MSTN^-/- pigs had myofibers with larger cross-sectional areas and higher fast-twitch gl

SUBMITTER: Luo ZB 

PROVIDER: S-EPMC10121221 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature