Using genomic scars to select immunotherapy beneficiaries in advanced non-small cell lung cancer.

ABSTRACT: In advanced non-small cell lung cancer (NSCLC), response to immunotherapy is difficult to predict from pre-treatment information. Given the toxicity of immunotherapy and its financial burden on the healthcare system, we set out to identify patients for whom treatment is effective. To this end, we used mutational signatures from DNA mutations in pre-treatment tissue. Single base substitutions, doublet base substitutions, indels, and copy number alteration signatures were analysed in [Formula: see text] patients (the discovery set). We found that tobacco smoking signature (SBS4) and thiopurine chemotherapy exposure-associated signature (SBS87) were linked to durable benefit. Combining both signatures in a machine learning model separated patients with a progression-free survival hazard ratio

SUBMITTER: Donker HC 

PROVIDER: S-EPMC10121673 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature