The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1⁺ precursors.

ABSTRACT: The intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets that locate in specific anatomical niches. Nevertheless, we find that the transcriptional profile of similar fibroblast subsets differs markedly between the small intestine and colon suggesting region specific functions. We perform in vivo transplantation and lineage-tracing experiments to demonstrate that adult intestinal fibroblast subsets, smooth muscle cells and pericytes derive from Gli1-expre

SUBMITTER: Pærregaard SI 

PROVIDER: S-EPMC10121680 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature