Predictive Modeling to Assess Pretest Probability of Transthyretin Gene Variants Based on Demographic Information.

ABSTRACT:

Background

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a morbid condition, though recent advances in diagnosis and therapy stand to change its natural history. Patients' TTR genotype may guide family screening as more treatments and preventive strategies become available. An efficient, intuitive means of determining pretest genetic risk may better inform patients/clinicians when pursuing genetic testing.

Methods

This is a cohort study of 767 consecutive patients diagnosed with ATTR-CM who underwent genetic testing. Classification and regression trees (CART) analysis created a decision tree assessing likelihood of carrying a pathologic TTR gene variant. Age, sex, and race were used as independent variables. Logistic regression was also performed to model p

SUBMITTER: Saef J 

PROVIDER: S-EPMC10121730 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature