Parental Age and Childhood Risk for Cerebral Palsy in California.

ABSTRACT:

Objective

To investigate the associations between maternal or paternal age at the time of delivery and offspring's risk for cerebral palsy (CP) in California.

Study design

We conducted a population-based, case-control study that included 8736 singleton CP cases and 90 250 singleton controls, matched by sex and birth year, selected from California birth certificate records from 1994 to 2010. We estimated OR and 95% CIs for CP diagnosis according to maternal and paternal age recorded on the birth certificates. Causal mediation analysis was performed to estimate direct and indirect effects of parental ages on CP with preterm delivery as a potential mediator.

Results

Children born to younger mothers (≤19 years) or older mothers (35-39 years; ≥40 years) had a greater risk

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10121738 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature