Reticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement: Age-Related Eye Disease Study 2 Report 32.

ABSTRACT:

Purpose

To determine whether reticular pseudodrusen (RPD) status, ARMS2/HTRA1 genotype, or both are associated with altered geographic atrophy (GA) enlargement rate and to analyze potential mediation of genetic effects by RPD status.

Design

Post hoc analysis of an Age-Related Eye Disease Study 2 cohort.

Participants

Eyes with GA: n = 771 from 563 participants.

Methods

Geographic atrophy area was measured from fundus photographs at annual visits. Reticular pseudodrusen presence was graded from fundus autofluorescence images. Mixed-model regression of square root of GA area was performed by RPD status, ARMS2 genotype, or both.

Main outcome measures

Change in square root of GA area.

Results

Geographic atrophy enlargement was significantly faster in e

SUBMITTER: Agron E 

PROVIDER: S-EPMC10121754 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature