Bioengineering and Clinical Translation of Human Lung and its Components.

ABSTRACT: Clinical lung transplantation has rapidly established itself as the gold standard of treatment for end-stage lung diseases in a restricted group of patients since the first successful lung transplant occurred. Although significant progress has been made in lung transplantation, there are still numerous obstacles on the path to clinical success. The development of bioartificial lung grafts using patient-derived cells may serve as an alternative treatment modality; however, challenges include developing appropriate scaffold materials, advanced culture strategies for lung-specific multiple cell populations, and fully matured constructs to ensure increased transplant lifetime following implantation. This review highlights the development of tissue-engineered tracheal and lung equivalents over

SUBMITTER: Derman ID 

PROVIDER: S-EPMC10121779 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature