Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia.

ABSTRACT: L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a side effect of Parkinson's disease treatment and it is characterized by atypical involuntary movements. A link between neuroinflammation and L-DOPA-induced dyskinesia has been documented. Hydrogen gas (H₂) has neuroprotective effects in Parkinson's disease models and has a major anti-inflammatory effect. Our objective is to test the hypothesis that H₂ inhalation reduces L-DOPA-induced dyskinesia. 15 days after 6-hydroxydopamine lesions of dopaminergic neurons were made (microinjection into the medial forebrain bundle), chronic L-DOPA treatment (15 days) was performed. Rats were exposed to H₂ (2% gas mixture, 1 h) or air (controls) before L-DOPA injection. Abnormal involuntary movements and locomo

SUBMITTER: Nascimento GC 

PROVIDER: S-EPMC10121822 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature