Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits.

ABSTRACT: Social experience is essential for the development and maintenance of higher-order brain function. Social deprivation results in a host of cognitive deficits, and cellular studies have largely focused on associated neuronal dysregulation; how astrocyte function is impacted by social deprivation is unknown. Here, we show that hippocampal astrocytes from juvenile mice subjected to social isolation exhibit increased Ca²⁺ activity and global changes in gene expression. We found that the Ca²⁺ channel TRPA1 is upregulated in astrocytes after social deprivation and astrocyte-specific deletion of TRPA1 reverses the physiological and cognitive deficits associated with social deprivation. Mechanistically, TRPA1 inhibition of hippocampal circuits is mediated by a parallel increa

SUBMITTER: Cheng YT 

PROVIDER: S-EPMC10121837 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature