Differential Gene Expression Among Patients With Heart Failure Experiencing Pain.

ABSTRACT:

Background

Chronic pain is frequently experienced by patients with heart failure (HF) and is associated with higher mortality, higher symptom burden, and worsened health-related quality of life. However, the genomic mechanisms underlying chronic pain in HF are understudied. Building an understanding of the mechanistic underpinnings of pain may inform novel interventions.

Objective

The objective was to identify genes associated with pain from messenger RNA sequence data collected from patients with HF with and without pain.

Methods

The current study analyzed data from 40 patients with HF previously enrolled in a clinical trial. Pain presence was measured using the Health Utilities Index Mark-3. Genes were tested for differential expression using DESeq2, and differentia

SUBMITTER: Smith AB 

PROVIDER: S-EPMC10121868 | biostudies-literature | 2023 May-Jun 01

REPOSITORIES: biostudies-literature