Acute pancreatitis induces a transient hypercoagulable state in murine models.

ABSTRACT:

Background/objectives

Although understudied, risk of venous thromboembolism (VTE) appears to be increased during acute pancreatitis (AP). We aimed to further characterize a hypercoagulable state associated with AP utilizing thromboelastography (TEG), a readily available, point of care test.

Methods

AP was induced in C57/Bl6 mice using l-arginine and caerulein. TEG was performed with citrated native samples. The maximum amplitude (MA) and coagulation index (CI), a composite marker of coagulability, were evaluated. Platelet aggregation was assessed using whole blood collagen-activated platelet impedance aggregometry. Circulating tissue factor (TF), the initiator of extrinsic coagulation, was measured with ELISA. A VTE model using IVC ligation followed by measurement of clot si

SUBMITTER: Rao P 

PROVIDER: S-EPMC10121939 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature