Combing fecal microbial community data to identify consistent obesity-specific microbial signatures and shared metabolic pathways.

ABSTRACT: Obesity is associated with altered gut microbiome composition but data across different populations remain inconsistent. We meta-analyzed publicly available 16S-rRNA sequence datasets from 18 different studies and identified differentially abundant taxa and functional pathways of the obese gut microbiome. Most differentially abundant genera (Odoribacter, Oscillospira, Akkermansia, Alistipes, and Bacteroides) were depleted in obesity, indicating a deficiency of commensal microbes in the obese gut microbiome. From microbiome functional pathways, elevated lipid biosynthesis and depleted carbohydrate and protein degradation suggested metabolic adaptation to high-fat, low-carbohydrate, and low-protein diets in obese individuals. Machine learning models trained on the

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10122048 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature