P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a non-specific chronic inflammatory disease of the intestine. In addition to genetic susceptibility, environmental factors and dysregulated host immunity, the gut microbiota is implicated in the pathogenesis of Crohn's disease (CD) or ulcerative colitis (UC), the two primary types of IBD. The P2X4 receptor has been demonstrated to have a crucial role in preventing infection, inflammation, and organ damage. However, it remains unclear whether the P2X4 receptor affects IBD and the underlying mechanisms.

Methods

Colitis was induced in mice administrated with dextran sodium sulphate (DSS). 16S rDNA sequencing was used to analyze the gut microbiota in knockout and wild-type mice. Clinical and histopathological parameters were monitor

SUBMITTER: Zhong P 

PROVIDER: S-EPMC10122071 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature