Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

ABSTRACT: A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor XII (FXII) triggers activation of the contact system that is known to be involved in both thrombosis and inflammation, but not in physiological hemostasis. Therefore, we investigated whether FXII contributes to the prothrombotic and inflammatory complications associated with SCD. We found that when compared with healthy controls, patients with SCD exhibit increased circulating biomarkers of FXII activation that are associated with increased activation of the contact pathway. We also found that FXII, but not tissue factor, contributes to enhanced thrombin generation and systemic inflammation observed in sickle

SUBMITTER: Sparkenbaugh EM 

PROVIDER: S-EPMC10122107 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature