Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery: A Randomized Clinical Trial.

ABSTRACT:

Importance

Epidural anesthesia is a primary choice for cesarean delivery, but supplemental analgesics are often required to relieve pain during uterine traction.

Objective

To investigate the sedative and analgesic effects of intravenous esketamine administered before childbirth via cesarean delivery with the patient under epidural anesthesia.

Design, setting, and participants

This multicenter, double-blind randomized clinical trial assessed 903 women 18 years or older who had full-term single pregnancy and were scheduled for elective cesarean delivery with epidural anesthesia in 5 medical centers in China from September 18, 2021, to September 20, 2022.

Intervention

Patients were randomized to receive intravenous injection of 0.25 mg/kg of esketamine or placebo

SUBMITTER: Xu LL 

PROVIDER: S-EPMC10122167 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature