Association of Overweight, Obesity, and Recent Weight Loss With Colorectal Cancer Risk.

ABSTRACT:

Importance

Overweight and obesity, conditions with rising prevalence in many countries, are associated with increased colorectal cancer (CRC) risk. However, many patients with CRC lose weight before diagnosis, which may lead the association to be underestimated.

Objective

To evaluate the association of body mass index (BMI) and weight change with CRC risk when considering BMI at different time frames, with the intention to account for prediagnostic weight loss.

Design, setting, and participants

This population-based case-control study was conducted in southwestern Germany between 2003 and 2021. Cases with a first diagnosis of CRC and controls (frequency matched by age, sex, and county) with comprehensive risk factor information and self-reported weight at different ti

SUBMITTER: Mandic M 

PROVIDER: S-EPMC10122181 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature