Asking informed consent may lead to significant participation bias and suboptimal cardiovascular risk management in learning healthcare systems.

ABSTRACT:

Background

The Utrecht Cardiovascular Cohort - CardioVascular Risk Management (UCC-CVRM) was set up as a learning healthcare system (LHS), aiming at guideline based cardiovascular risk factor measurement in all patients in routine clinical care. However, not all patients provided informed consent, which may lead to participation bias. We aimed to study participation bias in a LHS by assessing differences in and completeness of cardiovascular risk management (CVRM) indicators in electronic health records (EHRs) of consenting, non-consenting, and non-responding patients, using the UCC-CVRM as an example.

Methods

All patients visiting the University Medical Center Utrecht for first time evaluation of a(n) (a)symptomatic vascular disease or condition were invited to participate.

SUBMITTER: Zondag AGM 

PROVIDER: S-EPMC10122202 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature