A gene regulatory network inference model based on pseudo-siamese network.

ABSTRACT:

Motivation

Gene regulatory networks (GRNs) arise from the intricate interactions between transcription factors (TFs) and their target genes during the growth and development of organisms. The inference of GRNs can unveil the underlying gene interactions in living systems and facilitate the investigation of the relationship between gene expression patterns and phenotypic traits. Although several machine-learning models have been proposed for inferring GRNs from single-cell RNA sequencing (scRNA-seq) data, some of these models, such as Boolean and tree-based networks, suffer from sensitivity to noise and may encounter difficulties in handling the high noise and dimensionality of actual scRNA-seq data, as well as the sparse nature of gene regulation relationships. Thus, inferring larg

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10122305 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature