A multi-targeting bionanomatrix coating to reduce capsular contracture development on silicone implants.

ABSTRACT:

Background

Capsular contracture is a critical complication of silicone implantation caused by fibrotic tissue formation from excessive foreign body responses. Various approaches have been applied, but targeting the mechanisms of capsule formation has not been completely solved. Myofibroblast differentiation through the transforming growth factor beta (TGF-β)/p-SMADs signaling is one of the key factors for capsular contracture development. In addition, biofilm formation on implants may result chronic inflammation promoting capsular fibrosis formation with subsequent contraction. To date, there have been no approaches targeting multi-facted mechanisms of capsular contracture development.

Methods

In this study, we developed a multi-targeting nitric oxide (NO) releasing bionanom

SUBMITTER: Hwang P 

PROVIDER: S-EPMC10122329 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature