FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.

ABSTRACT:

Backgrounds

Renal fibrosis is a common pathologic process of most chronic kidney diseases (CKDs), becoming one of the major public health problems worldwide. Terminal fucosylation plays an important role in physiological homeostasis and pathological development. The present study aimed to explore the role of terminal fucosylation during kidney fibrogenesis and propose a possible anti-fibrosis treatment via suppressing aberrant terminal fucosylation.

Methods

We investigated the expression level of fucosyltransferase1 (FUT1) in CKD patients by using public database. Then, we further confirmed the level of terminal fucosylation by UEA-I staining and FUT1 expression in unilateral ureteral obstruction (UUO)-induced renal fibrosis mice. Immunostaining, qPCR, western blotting and w

SUBMITTER: Luo J 

PROVIDER: S-EPMC10122342 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature