Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration.

ABSTRACT:

Background

The endometrium, the inner lining of the uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, the regeneration of damaged endometrial tissues by administrating stem cells only is very challenging due to the lack of specific microenvironments and their low attachment rates at the sites of injury. In this context, various biomaterial-based scaffolds have been used to overcome these limitations by providing simple structural support for cell attachment. However, these scaffold-based strategies also cannot properly reflect patient tissue-specific structural complexity and thus show only limited therapeutic effects.

Method

Therefore, in the present study, we developed a

SUBMITTER: Park SR 

PROVIDER: S-EPMC10122345 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature