Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs against them: An in silico approach.

ABSTRACT: Monkeypox virus (mpox virus) outbreak has rapidly spread to 82 non-endemic countries. Although it primarily causes skin lesions, secondary complications and high mortality (1-10%) in vulnerable populations have made it an emerging threat. Since there is no specific vaccine/antiviral, it is desirable to repurpose existing drugs against mpox virus. With little knowledge about the lifecycle of mpox virus, identifying potential inhibitors is a challenge. Nevertheless, the available genomes of mpox virus in public databases represent a goldmine of untapped possibilities to identify druggable targets for the structure-based identification of inhibitors. Leveraging this resource, we combined genomics and subtractive proteomics to identify highly druggable core proteins of mpox virus. This was fol

SUBMITTER: Sahu A 

PROVIDER: S-EPMC10122558 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature