Peptide Helix-Y¹² as Potential Effector for Peroxisome Proliferator-Activated Receptors.

ABSTRACT: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of lipids and glucose metabolism, and immune response. Therefore, they have been considered pharmacological targets for treating metabolic diseases, such as dyslipidemia, atherosclerosis, and non-alcoholic fatty liver disease. However, the available synthetic ligands of PPARs have mild to significant side effects, generating the necessity to identify new molecules that are selective PPAR ligands with specific biological responses. This study aimed to evaluate some components of the atheroprotective and hepatoprotective HB-ATV-8 nanoparticles [the amphipathic peptide Helix-Y¹², thermozeaxanthin, thermozeaxanthin-13, thermozeaxanthin-15, and a set of glycolipids], as possible ligan

SUBMITTER: Carrillo-Tripp M 

PROVIDER: S-EPMC10122583 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature