Causal Relations Between Obstructive Sleep Apnea and Stroke: A Mendelian Randomization Study.

ABSTRACT:

Background

Previous studies of obstructive sleep apnea (OSA) in relation to stroke have been noted. However, the exact causality remains to be clearly defined. We aimed to adopt a two-sample Mendelian randomization study to investigate the causal effects of OSA on stroke and its subtypes.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted to evaluate the causal effect of OSA on stroke and its subtypes, including, based on publicly genome-wide association studies (GWAS) databases. The inverse variance weighted (IVW) method was used as the main analysis. MR-Egger regression, weighted mode, weighted median, and MR pleiotropy residual sum and outlier (MR-PRESSO) were performed methods and were adopted as supplementary analysis to ensure the robustness of th

SUBMITTER: Li P 

PROVIDER: S-EPMC10122861 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature