Modeling Opioid Abuse: A Case Study of the Opioid Crisis in New England.

ABSTRACT: For the past two decades, the USA has been embroiled in a growing prescription drug epidemic. The ripples of this epidemic have been especially apparent in the state of Maine, which has fought hard to mitigate the damage caused by addiction to pharmaceutical and illicit opioids. In this study, we construct a mathematical model of the opioid epidemic incorporating novel features important to better understanding opioid abuse dynamics. These features include demographic differences in population susceptibility, general transmission expressions, and combined consideration of pharmaceutical opioid and heroin abuse. We demonstrate the usefulness of this model by calibrating it with data for the state of Maine. Model calibration is accompanied by sensitivity and uncertainty analysis to quantify

SUBMITTER: Butler C 

PROVIDER: S-EPMC10122875 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature