Prognostic Value of the Intermediate-risk Feature in Men with Favorable Intermediate-risk Prostate Cancer: Implications for Active Surveillance.

ABSTRACT:

Background

Guidelines suggest that active surveillance (AS) may be considered for select patients with favorable intermediate-risk (fIR) prostate cancer.

Objective

To compare the outcomes between fIR prostate cancer patients included by Gleason score (GS) or prostate-specific antigen (PSA). Most patients are classified with fIR disease due to either a 3 + 4 = 7 GS (fIR-GS) or a PSA level of 10-20 ng/ml (fIR-PSA). Previous research suggests that inclusion by GS 7 may be associated with worse outcomes.

Design setting and participants

We conducted a retrospective cohort study of US veterans diagnosed with fIR prostate cancer from 2001 to 2015.

Outcome measurements and statistical analysis

We compared the incidence of metastatic disease, prostate cancer-specific mo

SUBMITTER: Sherer MV 

PROVIDER: S-EPMC10123417 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature