Organ preservation strategy: new therapeutic alternative in rectal cancer.

ABSTRACT:

Background

The therapeutic modalities for nonmetastatic rectal cancer are presently undergoing major changes. The standard treatment is multidisciplinary, combining radiotherapy, chemotherapy, and surgery. The aim of this minireview is to provide an update on the place of organ preservation in the treatment of nonmetastatic rectal cancer in 2022.

Main text

The multimodal strategy based on initial radiochemotherapy followed by radical surgery with excision of the mesorectum has improved oncological results but at the expense of morbidity and sequelae altering life quality. The strategy of rectal preservation has been proposed since the 2000s after the publication of the results of the Brazilian study that proposed a simple surveillance after radiochemotherapy without surgery

SUBMITTER: Safini F 

PROVIDER: S-EPMC10123594 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature