A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver.

ABSTRACT: During prenatal life, the foetal liver is colonised by several waves of haematopoietic progenitors to act as the main haematopoietic organ. Single cell (sc) RNA-seq has been used to identify foetal liver cell types via their transcriptomic signature and to compare gene expression patterns as haematopoietic development proceeds. To obtain a refined single cell landscape of haematopoiesis in the foetal liver, we have generated a scRNA-seq dataset from a whole mouse E12.5 liver that includes a larger number of cells than prior datasets at this stage and was obtained without cell type preselection to include all liver cell populations. We combined mining of this dataset with that of previously published datasets at other developmental stages to follow transcriptional dynamics as well as the ce

SUBMITTER: Ceccacci E 

PROVIDER: S-EPMC10123705 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature