Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study.

ABSTRACT: Previously, 3D-printed bone grafts made of titanium alloy with bioactive coating has shown great potential for the restoration of bone defects. Implanted into a medullary canal titanium graft with cellular structure demonstrated stimulation of the reparative osteogenesis and successful osseointegration of the graft into a single bone-implant block. The purpose of this study was to investigate osseointegration of a 3D-printed degradable polymeric implant with cellular structure as preclinical testing of a new technique for bone defect restoration. During an experimental study in sheep, a 20 mm-long segmental tibial defect was filled with an original cylindrical implant with cellular structure made of polycaprolactone coated with hydroxyapatite. X-ray radiographs demonstrated reparative bone

SUBMITTER: Popkov A 

PROVIDER: S-EPMC10123725 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature