Utilization of Genomic Tumor Profiling in Pediatric Liquid Tumors: A Clinical Series.

ABSTRACT: Hematologic tumors are mostly treated with chemotherapies that have poor toxicity profiles. While molecular tumor profiling can expand therapeutic options, our understanding of potential targetable drivers comes from studies of adult liquid tumors, which does not necessarily translate to efficacious treatment in pediatric liquid tumors. There is also no consensus on when profiling should be performed and its use in guiding therapies. We describe a single institution's experience in integrating profiling for liquid tumors. Pediatric patients diagnosed with leukemia or lymphoma and who underwent tumor profiling were retrospectively reviewed. Ten (83.3%) patients had relapsed disease prior to tumor profiling. Eleven (91.7%) patients had targetable alterations identified on profiling, and thre

SUBMITTER: Sharma I 

PROVIDER: S-EPMC10123750 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature