Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease.

ABSTRACT:

Objective

MUC5B and TOLLIP single nucleotide polymorphisms (SNPs) and cigarette smoking were associated with rheumatoid arthritis-interstitial lung disease (RA-ILD) in a predominantly Northern European population. We evaluated whether RA-ILD is associated with these genetic variants and HLA-DRB1 shared epitope (SE) alleles in a large RA cohort stratified by race and smoking history.

Methods

HLA-DRB1 SE alleles and MUC5B rs35705950 and TOLLIP rs5743890 SNPs were genotyped in U.S. veterans with RA. ILD was validated through medical record review. Genetic associations with ILD were assessed in logistic regression models overall and in subgroups defined by race and smoking status, with additive interactions assessed by the relative excess risk of interaction (RERI).

Results</

SUBMITTER: Wheeler AM 

PROVIDER: S-EPMC10123759 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature