In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review.

ABSTRACT:

Objective

The aim of this study was to catalog and evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms to improve clinical trials.

Methods

A systematic review of MEDLINE, Embase, and Scopus was conducted in April 2020. Seven criteria were applied to focus on original research that includes quantifiable response biomarkers measured alongside ASD symptoms. Interventional studies or human studies that assessed the correlation between biomarkers and ASD-related behavioral measures were included.

Results

A total of 5,799 independent records yielded 280 articles for review that reported on 940 biomarkers, 755 of which were unique to a single publication. Molecular biomarkers were the most frequently assayed, including cytokines, growth facto

SUBMITTER: Parellada M 

PROVIDER: S-EPMC10123775 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature