Lung transplant waitlist outcomes among ABO blood groups vary based on disease severity.

ABSTRACT:

Background

Blood group O candidates have lower lung transplantation rates despite having the most common blood group. We postulated that waitlist outcomes among these candidates and those with other blood types vary with disease severity and lung allocation score (LAS).

Methods

We performed a retrospective cohort study of 32,772 waitlist candidates using the United Network of Organ Sharing registry from May 2005 to 2020. After identifying an interaction between blood group and LAS, we evaluated the association between blood group and waitlist outcomes within LAS quartiles using unadjusted and adjusted competing risk models.

Results

In the lowest LAS quartile, blood group O had a 20% reduced transplantation rate (SHR: 0.80, 95%CI: 0.75-0.85) and higher waitlist death/r

SUBMITTER: Greissman S 

PROVIDER: S-EPMC10123800 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature