Suppressed activity of the rostral anterior cingulate cortex as a biomarker for depression remission.

ABSTRACT:

Background

Suppression of the rostral anterior cingulate cortex (rACC) has shown promise as a prognostic biomarker for depression. We aimed to use machine learning to characterise its ability to predict depression remission.

Methods

Data were obtained from 81 15- to 25-year-olds with a major depressive disorder who had participated in the YoDA-C trial, in which they had been randomised to receive cognitive behavioural therapy plus either fluoxetine or placebo. Prior to commencing treatment patients performed a functional magnetic resonance imaging (fMRI) task to assess rACC suppression. Support vector machines were trained on the fMRI data using nested cross-validation, and were similarly trained on clinical data. We further tested our fMRI model on data from the YoDA-A tria

SUBMITTER: Davey CG 

PROVIDER: S-EPMC10123826 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature