White matter, cognition and psychotic-like experiences in UK Biobank.

ABSTRACT:

Background

Psychotic-like experiences (PLEs) are risk factors for the development of psychiatric conditions like schizophrenia, particularly if associated with distress. As PLEs have been related to alterations in both white matter and cognition, we investigated whether cognition (g-factor and processing speed) mediates the relationship between white matter and PLEs.

Methods

We investigated two independent samples (6170 and 19 891) from the UK Biobank, through path analysis. For both samples, measures of whole-brain fractional anisotropy (gFA) and mean diffusivity (gMD), as indications of white matter microstructure, were derived from probabilistic tractography. For the smaller sample, variables whole-brain white matter network efficiency and microstructure were also derived

SUBMITTER: Bosma MJ 

PROVIDER: S-EPMC10123836 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature