Optics-Free, In Situ Swelling Monitoring of Articular Cartilage with Graphene Strain Sensors.

ABSTRACT: Articular cartilage derives its load-bearing strength from the mechanical and physiochemical coupling between the collagen network and negatively charged proteoglycans, respectively. Current disease modeling approaches and treatment strategies primarily focus on cartilage stiffness, partly because indentation tests are readily accessible. However, stiffness measurements via indentation alone cannot discriminate between proteoglycan degradation versus collagen degradation, and there is a lack of methods to monitor physiochemical contributors in full-stack tissue. To decouple these contributions, here, we developed a platform that measures tissue swelling in full-depth equine cartilage explants using piezoresistive graphene strain sensors. These piezoresistive strain sensors are embedded wit

SUBMITTER: Sundar S 

PROVIDER: S-EPMC10123914 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature