Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry.

ABSTRACT: The rapid and accurate authentication of traditional Chinese medicines (TCMs) has always been a key scientific and technical problem in the field of pharmaceutical analysis. Herein, a novel heating online extraction electrospray ionization mass spectrometry (H-oEESI-MS) was developed for the rapid and direct analysis of extremely complex substances without the requirement for any sample pretreatment or pre-separation steps. The overall molecular profile and fragment structure features of various herbal medicines could be completely captured within 10-15 s, with minimal sample (<0.5 mg) and solvent consumption (<20 μL for one sample). Furthermore, a rapid differentiation and authentication strategy for TCMs based on H-oEESI-MS was proposed, including metabolic profile characterization, char

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC10123936 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature