Hypoxia disrupt tight junctions and promote metastasis of oral squamous cell carcinoma via loss of par3.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is a highly malignant tumor that is frequently associated with lymph node metastasis, resulting in poor prognosis and survival in patients. In the tumor microenvironment, hypoxia plays an important role in regulating cellular responses such as progressive and rapid growth and metastasis. In these processes, tumor cells autonomously undergo diverse transitions and acquire functions. However, hypoxia-induced transition of OSCC and the involvement of hypoxia in OSCC metastasis remain unclear. Therefore, in this study, we aimed to elucidate the mechanism of hypoxia-induced OSCC metastasis and particularly, its impact on tight junctions (TJs).

Methods

The expression of hypoxia-inducible factor 1-alpha (HIF-1α) was detected in tumor t

SUBMITTER: Kim S 

PROVIDER: S-EPMC10123966 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature